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Inflammation and repair

Manchester is internationally recognised as a centre of expertise for research into inflammation and repair. We translate our interdisciplinary excellence in inflammation and regenerative medicine research and education into the highest quality, multi-professional care for patients with inflammatory diseases.

The domain works closely with The University of Manchester’s Infection, immunity, inflammation and repair strategic research domain. This spans basic, clinical and translational innovation at the interface of infection, immunity, inflammation and repair. Basic Science research is carried out in many divisions across the School of Biological Sciences, including Manchester Collaborative Centre for Inflammation and Repair, Arthritis Research UK Centres of Excellence in Genetics and Genomics, and Epidemiology, and in the Manchester Fungal Infection Group.

We also introduce new collaborative centres – designed to bring experts in academia and healthcare to work on innovative new treatments and ways of delivering care – and take advantage of some of the excellent facilities in Manchester.

We are leaders in stratified medicine, an approach that divides patients with a particular disease according to how they respond to therapies. The aim is to get the right treatment to the right person at the right time. We have significantly increased our stratified medicine infrastructure through the NIHR Manchester Biomedical Research Centre, the Manchester Molecular Pathology Innovation Centre with a focus on immune-mediated conditions, the Stoller Biomarker Discovery Centre and three Medical Research Council Stratified Medicine Consortia (Rheumatoid Arthritis, Psoriasis and Systemic Lupus Erythematosus ).

In our NIHR Manchester Biomedical Research Centre, we are driving forward pioneering research into new tests and treatments in musculoskeletal disease, hearing health, respiratory disease, dermatology and three cancer themes (prevention, radiotherapy and precision medicine), utilising our expertise in biomarkers, informatics and the rapid translation of research findings.

Objectives

Achievements

  • Our Virtual Biologics Clinic has led to improved disease and symptom control in patients with inflammatory arthritis, through improvements to biologic prescribing; the number of patients classified as good responders to biologics therapy increased by over 10% between 2011 and 2014, from 39% to 54%. As a result, virtual biologics clinics have been established in four other NHS trusts in the North West region and one in Scotland. We now aim to use similar concepts to improve response to other medications, such as methotrexate.
  • The Manchester Psoriasis Research Group has been integral in the development, trialling, NICE approval and NHS implementation of all biologic therapies for psoriasis, which has transformed management of severe disease. The 2015 NICE approval for a first biologic was supported by work in Manchester, as was the European Medicines Agency approval of a second biologic in 2016.
  • Major trauma caseload in Greater Manchester is one of the largest in Europe. The burden of associated health and social problems is significant and its economic impact substantial. Our changes to Major Trauma service provision in Greater Manchester have led to significant improvements in survival rates from major trauma.
  • Acute kidney injury (AKI), a rapid reduction in kidney function, occurs in up to one in five patients admitted to hospital. Our successful AKI quality improvement programme significantly reduced the impact of AKI across Central Manchester Universities Hospital NHS Foundation Trust.
  • We have significantly increased clinical and non-clinical training fellowship numbers, expanded training for Healthcare Scientists and developed new training programmes in Manchester. We encourage undergraduate medical students to start thinking about linking research and clinical practice through running an annual funding competition for research projects.

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