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Cardiovascular

The Cardiovascular Domain applies discovery and translational science, and excellence in clinical care, to improve life expectancy for patients with cardiovascular disease in Greater Manchester.

Greater Manchester is one of the largest population catchments for tertiary cardiac services in Europe and offers a unique resource for clinical research. This is also combined with training the next generation of healthcare staff and researchers to the highest standard. Through the strengths and catchment populations of our partners, we will take early discovery and innovation from basic underpinning research into practice, prove effectiveness, and disseminate best practice across our region.

Greater Manchester’s population suffers disproportionately from heart and circulatory disease. Our services include large tertiary cardiac units (Central Manchester University Hospitals NHS Foundation Trust and University Hospital of South Manchester) that, together, provide the highest quality specialist care to a population of around 3.5 million people, with additional provision of nationally designated cardiopulmonary transplantation and ventricular assist services to 6.6 million people.

Stroke is a devastating condition affecting people of all ages, causing death and long-term disability. Following changes to GM hospital stroke services in 2015 to ensure patients have access to better quality hospital care and timely specialist treatment, Greater Manchester now has the best scoring hospital stroke pathway in the country, with all stroke patients having access to care rated as ‘A’ (the highest available rating) by The Sentinel Stroke National Audit Programme. Stroke research is an important part of stroke services and a major research strength in Manchester. A wide range of studies involving stroke and the emergency conditions affecting the brain, take place at Salford Royal NHS Foundation Trust.

The University of Manchester’s Division of Cardiovascular Sciences combines clinical, translational and basic science research with the aim of translating our understanding of the cellular and molecular processes underlying cardiovascular disease into improved clinical treatments and patient care.

We focus on three research areas: Hypertension and its consequences; Cardiac physiology and heart failure; and Cardiovascular Genomics. These research strengths are interdisciplinary, feature strong international collaborations and address global cardiovascular health challenges. The university’s Division of Diabetes, Endocrinology and Metabolism comprises internationally leading researchers into endocrine organ development, diabetic complications, the neuronal control of appetite, and circadian clocks in cardiometabolic disease.

In addition, the disease burden on North West England is particularly high for common diseases such as diabetes. Our successful research programmes aim to improve the screening and treatment of this disease.

The Cardiovascular Domain links basic science and transitional strength in The University of Manchester’s Cardiovascular, Endocrine and Metabolic Sciences Strategic Research Domain, with cardiac and stroke care centres in the acute trust partners, applied research in the Greater Manchester Collaboration for Leadership in Applied Health Research and Care and the implementation of research in clinical practice via the academic health science network and public health initiatives across the region. The integration of these activities will enable us to improve the identification and management of cardiovascular risk, conduct translational research and enhance care delivery in Manchester and beyond.

Objectives

Achievements

Landmark research on Explaining outcomes in major system change: a qualitative study of implementing centralised acute stroke services in two large metropolitan regions in England.

  • A key project in the Connected Health Cities programme to improve the diagnosis and treatment of strokes.
  • AF Data Landscape Tool standardises a Manchester-wide approach to improve the care pathway for those at risk of an Atrial Fibrillation related stroke.
  • Substantial reduction in amputations in diabetic foot disease.
  • World leading studies of the genomics of congenital heart disease, hypertension and coronary artery disease.
  • Practice-changing innovations in the detection and management of non-adherence to antihypertensive therapy.
  • Groundbreaking research showing the benefits of Sildenafil (Viagra) on mortality in diabetes.
  • Practice-changing research studies using national audit databases to quantify the greater safety of coronary angioplasty via the radial rather than the femoral artery.
  • Using genetics to discover hitherto unexpected side-effects of cardiovascular drugs, thus improving patient safety.
  • Establishment of a regional, integrated service, provided between Cardiology and Clinical Genetics at CMFT, for patients with Marfan’s Syndrome and other Genetic Aortopathies – resulting in measurable improvements in care in Greater Manchester and beyond.
  • Studies identifying genes which affect sleep timing preference (“larks” or “owls”) and showing the relationship between genes affecting sleep disturbance and cardiometabolic risk.
  • Manchester’s national leadership in intelligent transparency as a means of improving NHS services in partnership with the National Institute for Cardiovascular Outcomes Research. Our initial work was on cardiac surgery and, via the Healthcare Quality Improvement Partnership, this now encompasses other specialities.

Familial Hypercholesterolaemia programme

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CVD programme

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AF programme

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