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Clinical research excellence

Our ambition is for Greater Manchester, one of the UK’s three biomedical clusters, to become a world-leading location for clinical research.  

The region’s single health and social care system is now providing greater impetus to deliver clinical research at pace and scale, where every patient is provided with the opportunity to be involved in research because it is at the heart of our innovative clinical practice. This will deliver both better health outcomes and economic growth.

In taking our research ambitions forward, we are supported by first-rate people, services and infrastructure. This ranges from an internationally recognised NIHR biomedical research centre and clinical research facility, through to bespoke services, designed to support and facilitate the research process, for example, the Greater Manchester Research Hub and our Clinical Trials Unit.

Excellence in experimental medicine

Health Innovation Manchester is a centre of excellence, strength and depth in experimental medicine and translational research.

Research within experimental medicine spans fundamental discovery science to translational approaches, which include early phase clinical trials.

Our strategic approach to research is through the lens of P4 Medicine: to prevent disease, predict disease progression, personalise treatment pathways and empower patients to participate in their healthcare.

This P4 Medicine approach is applied through all our research and cross-cutting themes (as shown in the diagram below) to provide opportunities for sharing expertise and discoveries, in order to deliver efficient experimental research that maximises synergies across our partnership and accelerates discoveries through to routinely commissioned care.

Strategic aims: research and cross-cutting themes

Our research objectives directly address those clinical areas that are the major causes of premature death and high disability in Greater Manchester. These strategic aims are:

  • Musculoskeletal – produce a step change in health outcomes and accelerate discoveries into routinely commissioned care, at scale, in the shortest possible time
  • Cancer Prevention & Early Detection – better understand biology-behaviour-environment interactions, which impact on the approach to endotype discovery, clinical prediction, medication behaviours and early trials
  • Hearing health – improve the lives of people with hearing loss by preventing potentially devastating congenital deafness, diagnosing acquired age-related deficits and developing new treatments
  • Cancer Advanced Radiotherapy – drive national and international innovations and translate advances into patient benefit by predicting disease progression and personalising treatments to ‘Treat Smarter’
  • Respiratory – deliver experimental medicine research to a range of clinical problems in respiratory diseases, from the treatment of complex critically ill patients to the palliation of symptoms in chronic disorders
  • Cancer Precision Medicine – Manchester’s NIHR/CRUK Experimental Cancer Medicines Centre (ECMC) provides a conducive environment to develop and test precision medicine for patient benefit
  • Dermatology – prevent and predict disease progression and personalise treatment for inflammatory skin disease and chronic wounds

Cross-cutting themes

  • Biomarker Platforms – capitalise on our state-of-the-art infrastructure for biomarker discovery, development and translation, in a way that habitually drives implementation into routinely commissioned healthcare
  • Informatics and data sciences – develop and apply new approaches, allowing integration of rich datasets to enable new pathway discovery and allow ongoing calibration of predictive models
  • Rapid Translational Incubator – accelerate biomedical and clinical discoveries through improved efficiency and specific support for early phase trial
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Cancer

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Mental health

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Population health and implementation

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Women and children

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Cardiovascular

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Inflammation and repair

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